Oct 15, 2021
A New Approach to Lyme Disease
Here's a new paper with what might be an interesting approach to Lyme disease (and here's Nature on this story). As it stands, Lyme is treated with a pretty stiff course of some...
Sep 29, 2021
Biogen's Alzheimer's Drug Is Not Doing Well
Since the FDA approved Biogen's aducanumab (brand name Aduhelm) as an antibody for Alzheimer's therapy - a decision I thought was a ruinous mistake - we've been seeing some...
Sep 12, 2021
Vaccines Will Not Produce Worse Variants
Let's jump back into the coronavirus world and cover a question that I (and many others) have been fielding - President Biden's announcement of tougher vaccine mandates in the US are...
Jul 25, 2021
More Protein Folding Progress – What’s It Mean?
I last wrote about Deepmind’s efforts to predict protein folding and structure here, with their AlphaFold software. AlphaFold really performed very strongly in the 2020 protein...
Jul 19, 2021
A Fifty-Year-Old Cancer Drug Doesn’t Do What You Think
5-fluorouracil (5-FU) has been around a long time now (over fifty years), and it’s a standard oncology drug (particularly in colorectal treatment regimes). But try going around...
Jun 25, 2021
Floodgates Open for Alzheimer's Drugs That Don't Work
It should be obvious, given previous posts here, that I think that the FDA approval of Biogen’s aducanumab for Alzheimer’s was a mistake. It is a mistake for a whole list...
Apr 4, 2021
Mysteries in Human RNA
Let’s put this one in the category of “more things that we didn’t know about human biology”. We’ve known for some time now about ribozymes –...
Mar 18, 2021
The Problem With COVID Clinical Trials
Let’s talk about a painful subject. I am of the opinion – and I’m far from alone – that the most reliable way to determine if a possible therapy has any...
Feb 21, 2021
How Antidepressants Work, At Last?
Over the years I’ve very much enjoyed being startled by the scientific literature, and there haven’t been many times when I’ve been more surprised than I was this...
Feb 3, 2021
Myths of Vaccine Manufacturing
In the last few days, the question of why more drug companies haven’t been enlisted for vaccine production has come up. It’s mostly due to this tweet...
Jan 22, 2021
mRNA Vaccines: What Happens at the Cellular Level
A question that comes up a lot about mRNA vaccines is what happens at the cellular level after you’re injected with one. The mechanism of any such vaccine is to cause cells to...
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