Derek Lowe

Author Archive

  • Oct 15, 2021
    Here's a new paper with what might be an interesting approach to Lyme disease (and here's Nature on this story). As it stands, Lyme is treated with a pretty stiff course of some...
  • Sep 29, 2021
    Since the FDA approved Biogen's aducanumab (brand name Aduhelm) as an antibody for Alzheimer's therapy - a decision I thought was a ruinous mistake - we've been seeing some...
  • Sep 12, 2021
    Let's jump back into the coronavirus world and cover a question that I (and many others) have been fielding - President Biden's announcement of tougher vaccine mandates in the US are...
  • Jul 25, 2021
    I last wrote about Deepmind’s efforts to predict protein folding and structure here, with their AlphaFold software. AlphaFold really performed very strongly in the 2020 protein...
  • Jul 19, 2021
    5-fluorouracil (5-FU) has been around a long time now (over fifty years), and it’s a standard oncology drug (particularly in colorectal treatment regimes). But try going around...
  • Jun 25, 2021
    It should be obvious, given previous posts here, that I think that the FDA approval of Biogen’s aducanumab for Alzheimer’s was a mistake. It is a mistake for a whole list...
  • Apr 4, 2021
    Let’s put this one in the category of “more things that we didn’t know about human biology”. We’ve known for some time now about ribozymes –...
  • Mar 18, 2021
    Let’s talk about a painful subject. I am of the opinion – and I’m far from alone – that the most reliable way to determine if a possible therapy has any...
  • Feb 21, 2021
    Over the years I’ve very much enjoyed being startled by the scientific literature, and there haven’t been many times when I’ve been more surprised than I was this...
  • Feb 3, 2021
    In the last few days, the question of why more drug companies haven’t been enlisted for vaccine production has come up. It’s mostly due to this tweet...
  • Jan 22, 2021
    A question that comes up a lot about mRNA vaccines is what happens at the cellular level after you’re injected with one. The mechanism of any such vaccine is to cause cells to...