"Rogue" Protein Could Contribute to High Cancer Rates

Liquid biopsy platform for early cancer screening being developed by Lucence in partnership with Waseda University (Photo: Business Wire)

Among a group of cell surface proteins known as sialic-acid-binding immunoglobulin-like lectins (Siglecs), CD33-related Siglecs are found mainly on innate immune cells and are involved in cell signaling. One Siglec, however, appears to have “gone rogue” in humans, according to Ajit and Nissi Varki, a husband-and-wife team at the UC San Diego School of Medicine.

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