CRISPR Produces Unwanted DNA Deletions

CRISPR Produces Unwanted DNA Deletions
Cailey Cotner/UC Berkeley via AP

Researchers have embraced CRISPR gene-editing as a method for altering genomes, but some are cautioning that unwanted DNA changes may slip by undetected.

The tool can cause large DNA deletions and rearrangements near its target site on the genome, according to a paper published on 16 July in Nature Biotechnology1. Such alterations can muddle the interpretation of experimental results and could complicate efforts to design therapies based on CRISPR.

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