It's a sweeping inquiry to be sure -- one open to dispute -- but if there's one person qualified to answer it, it would probably be Simonton. A distinguished professor at UC-Davis, Simonton has devoted more than three decades to studying scientific genius, and literally wrote the book on it.
In describing scientific genius, Simonton insists that while the creative scientist contributes ideas that are original and useful, the genius scientist tenders notions that also surprise. Instead of merely extending established knowledge, the genius scientist engineers novel expertise and provokes momentous leaps.
Sadly, in Simonton's opinion, scientific genius is in short supply, and likely extinct. In his Nature commentary, he writes:
"...in my view, neither discipline creation nor revolution is available to contemporary scientists." Our theories and instruments now probe the earliest seconds and farthest reaches of the Universe, and we can investigate the tiniest of life forms and the shortest-lived of subatomic particles. It is difficult to imagine that scientists have overlooked some phenomenon worthy of its own discipline alongside astronomy, physics, chemistry and biology... Future advances are likely to build on what is already known rather than alter the foundations of knowledge."
Simonton's thesis seems to hinge on the view that modern science is set; that through mankind's prodigious gaze, we have seen almost everything there is to see. The dots have been discovered, arranged, and numbered. All we have to do now is connect them. But as Neil deGrasse Tyson reminds us in his book, Death by Black Hole, we've heard this before. In 1901, the preeminent physicist Lord Kelvin boldly stated, "There is nothing new to be discovered in physics now. All that remains is more and more precise measurement." Kelvin may have been right about the temperature of absolute zero (-273.15 Celsius), but he sure was wrong about that. (Albert Einstein unveiled the groundbreaking special theory of relativity a mere four years later.)
Much has undeniably changed in 112 years, but Simonton's praise for humanity's scientific prowess seems simply a rehash of Kelvin's misguided over-confidence. Yes, mankind has accomplished many amazing things, but given the bewilderingly monumental scope of creation, there are surely more revolutionary advancements to be made, and more surprises waiting.
Is "Big Science" Destroying Genius?
However, concerning "big science," Simonton makes a legitimate point. He states, "Natural sciences have become so big, and the knowledge base so complex and specialized, that much of the cutting-edge work these days tends to emerge from large, well-funded collaborative teams involving many contributors."
It's true: the manner in which the majority of science is conducted today is hemmed into a set system. Mostly, it revolves around attaining funding and working together in large groups. This large, publication-centered, interconnected system, with common knowledge and set rules, has its benefits, but it also turns science into a factory. Sure, it keeps the cogs turning, but it may also hamper true creativity and genius, which, as elegantly stated by Scientific American's Ingrid Wickelgren, "depends on an unfiltered view of the world, one that is unconstrained by preconceptions and more open to novelty."
Moreover, with such arduous competition for limited scientific funds, the pie-in-the-sky ideas that may potentially hide brilliance underneath, are often ignored, abandoned, or simply never undertaken in the first place.
Simonton's fear is that "surprising originality" is a thing of the past. We certainly aren't there yet, but we may be headed down that unfortunate path.

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A major source of cooties.
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Sticking a flaming piece of fabric into your ear:
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A good friend of mine works as a meteorologist over at
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