November 5, 2012
Sequencing DNA, One Cell at a Time
Brian Owens, Nature News
All Nicholas Navin needed was one cell — the issue was how to get it. It was 2010, and the postdoctoral fellow at Cold Spring Harbor Laboratory in New York was exploring the genetic changes that drive breast cancer. Most of the cancer-genome studies before then had ground up bits of tumour tissue and sequenced the DNA en masse, giving a consensus picture of the cancer’s genome. But Navin wanted to work out the sequence from individual cells to see how they had mutated and diverged as the cancer grew.
TAGGED: DNA sequencing