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After six articles from a single research group—the laboratory of Naoki Mori at the University of the Ryukyus in Japan—were retracted from Infection and Immunity earlier this year, Editor-in-Chief Ferric Fang did some soul searching. He and Arturo Casadevall, editor-in-chief of the American Society for Microbiology journal mBio and Fang’s long-time friend and colleague, decided to explore the issue more deeply in an editorial published this week (August 8) in Infection and Immunity.